The match will be held at the Emirates Stadium, and will be shown live on ITV 1 and Sky Sports.
The Gunners are looking to lift this trophy for the first time since the 1992/93 season, and a hat-trick from Gabriel Jesus helped them to a 3-2 win over Crystal Palace here in the previous round.
Newcastle have never won this competition, but they were runners-up for the second time two seasons ago when they lost to Manchester United.
This time around, they were 3-1 home winners over Brentford in the last eight, having also overcome Chelsea in the fourth round.
ITV’s coverage begins at 7.30pm, where Mark Pougatch will be joined by Ian Wright and Les Ferdinand with match commentary by Sam Matterface and Lee Dixon.
Kick-off 8.00pm
Sky’s coverage gets underway at 7.00pm on Sky Sports Football and Sky Sports Main Event. Sky will also air Tottenham’s clash with Liverpool on Wednesday evening.
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The running order for tonight’s Match of the Day is as follows: 1: Tottenham Hotspur v Newcastle United; 2: Manchester